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Document 5: Pre-1950 Sources Describing Injections of Various Substances Other than Silver

May 3, 2004

Robert C. Holladay, MS

Copyright 2004 Robert C. Holladay


(1) Weil, Richard.  1913.  The effects of colloidal copper with an analysis of the therapeutic criteria in human cancer.  Journal of the American Medical Association.  61: 1034-1040.

            German and French doctors have used intravenous injections of colloidal metals to treat cancer with remarkable improvement and several complete recoveries. 

            Weil gave 7 cancer patients intravenous injections of colloidal copper over a period of about a month.  An average of 10.35 liters was injected, and each liter contained about 30 mg of copper.  An average of about 22 injections were given.  The treatment was not effective in decreasing the size of the tumors. 

            In other studies, the injections were often accompanied by a rise of temperature and a chill.  These symptoms were seen in some of Weil’s patients, along with nausea and anemia.  Weil concludes that the colloidal copper exerts a toxic influence on red blood cells.


(2) Clark, Guy W.  1918.  Effects of intravenous injections of a colloid (gelatin), upon rabbit sera.  Journal of Immunology.  3: 147.

            Four rabbits were injected with 20 cc of a 10% gelatin solution or 10 cc of a 20% gelatin solution.  No controls were used.  The injections showed no effect on the ratio or total amount of albumins, globulins, or non-proteins.  After injection of the protein, it is eliminated at a constant rate until it is completely absent, 6-24 hours after the injection. 

            Describes an experiment by Bulgia in which gelatin was intravenously injected into dogs but remained in the blood for as long as 40 hours after the injection.  The quantity of the injection was not mentioned.


(3) Herrman, Seigfried  F.  1918.  Liberation of antibodies on injection of foreign proteins.  Journal of Infecitous Diseases.  23: 457-469.

            Many reports have been published which state that the injection of foreign proteins will aid the treatment of an infectious disease.  Various proteins have been used including chicken serum, whole blood, horse serum etc.


(4) Cowie, David Murray and Greenthal, Roy Mark.  1921.  Studies on the action of non-specific protein in disease processes.  Journal of Medical Research.  42: 261-268.

            A previous study indicated that a guinea pig injected with horse serum would have a higher survival rate when injected with diphtheria toxin.

            Kastenmeyer reports the survival rate of pigs injected with horse serum and diphtheria toxin was greater than diphtheria toxin alone.

            An experiment was conducted in which dozens of pigs were injected with horse toxin and diphtheria toxin or only diphtheria toxin.  The survival rate among pigs injected with horse serum was higher than pigs injected with only diphtheria.

            A questionable method was employed to separate the protein portion from the non-protein portion of the horse serum.  Pigs were injected with either diphtheria and protein-containing horse serum or diphtheria and horse serum containing no protein.  The survival rate of pigs injected with serum containing horse protein was higher than the survival rate of pigs receiving horse serum containing no protein.      

            1 cc of horse serum was injected in most pigs.


(5) Mackie, T.J.  1923.  Observations on the protective action of normal serum in experimental infection with bacillus diptheriae.  Journal of Immunology.  8: 35-45.

            Performed experiments in which diphtheria toxin and various animals serum was injected subcutaneously into small numbers of guinea pigs.  Delaying the injection of serum 2 hours or more after injection of diphtheria provided less protection against the diphtheria.


(6) Stone, William S. and Lloyd F. Craver.  1927.  The colloidal lead treatment of malignant neoplasms.  Annals of Surgery.  86: 347-361.

            Bell has published literature which suggests that colloidal lead has a therapeutic action on tumors.

            Research done by Wood generally does not agree with Bell’s findings.

            Martland’s work on 15 patients also does not support Bell’s findings.  He injected stable colloidal lead in large quantities without producing immediate toxicity, however, several patients suffered from lead poisoning.

            Coke and Cook used smaller doses than Bell and report “a few favorable clinical results.”

            An experiment was performed in which 21 patients with tumors were given injections of colloidal lead.  In these 21 cases “the disease is well advanced.”

            A colloidal lead solution was manufactured by electrolysis.  After 4 weeks the colloidal lead solution was still stable.  This solution appeared to be far more stable than colloidal lead solutions used by Bell.   Colloidal lead solutions 2 hours to 9 days old were used for intravenous injections.  Bell recommended 6 injections of 100 milligrams each, but these doses were found to be unsafe and uncomfortable for the patients. 

            50-90 milligrams per injection was given over a period of several months.  The largest total injection was 375 milligrams.  The time intervals between injections varied from 5 days to several months. 

            In a trial run, 10 milligrams was injected in a solution of 0.4% gelatin.  A violent reaction followed with a severe chill, followed by a rise in temperature to 103 degrees F.  The pulse became feeble and cyanosis occurred.  An intravenous injection of adrenalin quickly made the severe effects subside.  Later, in the same patient 30 milligrams of colloidal lead without gelatin was injected and no reaction occurred.  The gelatin was omitted from all other injections.

            Side effects from the intravenous colloidal silver injections included the following: Sensations of burning and tingling, especially on the face, nausea and vomiting, abdominal cramps, dizziness, headache, haematuria, anemia.  Nausea and vomiting was the most common side effect, and it was present after most injections.  Only one case of extreme anemia occurred.  The maximum loss of red blood cells was 1888000 within 48 hours after injection.  The minimum loss of red blood cells was 240000 within seven days after injection.  Moderate leukocytosis was seen in ten patients.  None of the patients exhibited signs of lead poisoning after the treatment.  The tumor growth in 8 of the 21 patients regressed, but none were cured. 

            “It does not appear to us that the intravenous injection of lead offers a cure for malignant tumors.”


(7) Ullman, H.J.  1927.  The combination of colloidal lead and irradiation in cancer therapy.  Journal of the American Medical Association.  89: 1216-1218.

            Four other authors have suggested that the anemia from lead poisoning is the result of lead destroying the red blood cells.


(8) Schreiner, Bernhard F. and Reinhardt C. Wende.  1929.  Advanced cancer treated by colloidal lead.  Surgery, Gynecology & Obstetrics.  48: 115-118.

            Colloidal lead was manufactured from radioactive lead.  Nineteen patients with advanced cancer were given intravenous injections of radioactive colloidal lead.  A dosage of 0.025 grams was gradually increased to 0.1 gram over a period of 5-6 weeks. 1-10 injections were given.  General side effects included chills, nausea, vomiting, expectoration of blood, haematuria, weakness, loss of appetite.  After 0.1 gram of lead was administered, 10% to 60% of hemoglobin was lost within 2 to 5 days.  “No clinical improvement in the tumor was noted in any case treated in this series.”


(9) Gregersen, Magnus I., and Ruth A. Dawson.  1943.  The disappearance of T-1824 and structurally related dyes from the blood stream.  American Journal of Physiology.  138: 698-707.

            Four adult dogs received 3-5 cc intravenous injections of a 0.5% solution of 4 different dyes, and the rate of elimination from the bloodstream was measured.  After 40 minutes the concentration in the bloodstream was D-1836: 55%, T-1836: 70%, D-1824:  90% and T-1824: 96%.

            Rawson found that the dyes used in this experiment combine with albumin when mixed with serum. 


(10) Baillif, Ralph N.  1948.  Ovarian response in the albino rat to injected colloidal substances.  American Journal of Anatomy.  83: 109-141.

            It has been shown that intraperitoneal injections of colloidal substances are “rapidly removed from the peritoneal cavity and distributed throughout the body…The injected colloidal material is carried to all parts of the body by way of the blood-vascular system, and, depending somewhat on availability in any particular location, is taken up at least minimally by all tissues except those composing the central nervous system.”

            Colloidal particles are ingested by phagocytes and are enclosed in fluid vacuoles.


(11) Dobson, Ernest L.  et al.  1949.  Studies with colloids containing radioisotopes of yttrium, zirconium, columbium, and lanthanum.  Journal of Laboratory and Clinical Medicine.  34: 305-312.

            Intravenous injections of colloids were given to various animals.  When “large colloids” were injected, half the particles were removed from the blood stream in 6.5 minutes.  When particles of “intermediate size” were injected, half of them were removed from the bloodstream in 30-80 minutes.